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Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by Hepatitis C virus core protein

from American Journal of Pathology

Hepatic steatosis and insulin resistance are factors that aggravate the progression of liver disease caused by hepatitis C virus infection. In the pathogenesis of liver disease and metabolic disorders in HCV infection, oxidative stress due to mitochondrial respiratory chain dysfunction plays a pivotal role. Tacrolimus (FK506) is supposed to protect mitochondrial respiratory function. more

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