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Genome sequencing study offers clues about basal-like breast cancer metastasis

from GenomeWeb News

A Washington University-led research team reported that they have sequenced a quartet of genomes originating from an African-American woman with basal-like breast cancer. By sequencing the primary breast tumor, a brain metastasis, matched normal tissue, and a mouse xenograft developed from the primary tumor, the researchers were able to identify mutations shared in all of the tumors as well as genetic changes that were enriched — or found exclusively — in metastatic tissue. The research appears online in Nature. more

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