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Gene variant indicates rate of progression of Alzheimer's disease

from Medscape Medical News

A variant of a gene coding for tau protein is the first genetic marker to be associated with the rate of progression of Alzheimer's disease, according to an online report published in the Public Library of Science. Decreased amyloid beta levels in the cerebrospinal fluid have been associated with risk and age of onset of AD, with the change in Aβ levels preceding clinical signs of disease. Levels vary inversely with plaque counts, with the decrease probably a result of Aβ deposition in the brain. more


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