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Hairy-cell leukemia disease-defining
mutation identified


from Medscape Medical News

A mutation known as BRAF V600E has been identified in 100 percent of hairy-cell leukemia cases but in none of the peripheral B-cell lymphomas and leukemias tested, suggesting that this mutation is a disease-defining characteristic. The finding "provides valuable insight" into the disease, says an expert, and potentially opens up new avenues for diagnostic testing and opportunities for targeted drug therapy (such as with BRAF inhibitors, which are already being studied in melanoma). more


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