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Vemurafenib will open floodgates for melanoma genotyping

from Internal Medicine News

The genotyping era of melanoma management will start with genetic assessment of every patient with advanced-stage melanoma becoming the standard of care, as soon as the Food and Drug Administration approves marketing of vemurafenib, the small-molecule inhibitor of a mutated form of the BRAF gene. Results from genotyping studies of metastatic melanoma tumors have shown a BRAF mutation prevalence of about 43 percent and a NRAS mutation prevalence of about 14 percent, with the remaining 43 percent of tumors having wild type forms of both genes. more


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