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Snapback primer genotyping of the Gilbert syndrome, promoter polymorphism by high-resolution melting

from Clinical Chemistry

Gilbert syndrome is associated with thymine-adenine insertions in the UGT1A1 promoter. The UGT1A1 promoter genotype also correlates with toxicity induced by the chemotherapeutic drug irinotecan. Current closed-tube assays for genotyping the UGT1A1 promoter polymorphism require multiple labeled probes. more

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