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hs-CRP: What is proven and unproven?

from Medscape Genomic Medicine (May 19, 2011)

A recent large meta-analysis of genome-wide association studies from 15 cohort studies comprising 66,185 subjects and a replication sample of 16,540 subjects identified 18 gene loci associated with C-reactive protein levels. These 18 gene loci were mostly associated with immune response and metabolic regulatory pathways involved in the regulation of chronic inflammation. The authors developed a genetic risk score that explains about 5 percent of the variation in CRP levels, showing that genetic factors are important in determining CRP levels. more

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