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Active Voice: Repeated Eccentric Exercises Modify Human Muscle Proteome

from By Bernard Rogister, M.D., Ph.D.

Viewpoints presented in SMB commentaries reflect opinions of the authors and do not necessarily reflect positions or policies of ACSM.

Bernard Rogister, M.D., Ph.D., is Professor of Biochemistry and Physiology in the Medical School at the University of Liège (ULg) in Belgium. As a neuroscientist, his main research focuses on several aspects of developmental neurobiology and stem cells. However, he also has begun collaborating with Jean Louis Croisier, Professor of Physiotherapy (ULg), in order to unravel the molecular mechanisms of muscle damage following eccentric contractions. This commentary presents Dr. Rogister’s views associated with the research article he and his colleagues published in the Dec. 2011 issue of Medicine & Science in Sports & Exercise® (MSSE).

Eccentric (lengthening) muscle contraction frequently induces delayed-onset muscle soreness (DOMS), characterized by muscle pain, impairment of muscle function, stiffness, swelling and reduced range of motion. DOMS typically sets in a few hours after the eccentric exercise and will subsist for a few days, delaying the training program and/or the athlete’s exercise rehabilitation protocol. Histological studies have demonstrated various forms of sarcomeric disruption and membrane leakage that were associated with the presence of creatine kinase in the blood. An intriguing effect is the repeated bout effect. When a muscle has been conditioned by prior eccentric contractions, the magnitude of changes in muscle damage markers after later eccentric contractions is attenuated, constituting a muscle adaptation process. more

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