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Normal breast protein linked to cancer development

from Doctors Lounge

Trefoil protein, which maintains the integrity of the epithelial surface in the normal breast, is highly expressed in well-differentiated tumors, correlating with low histological grade, and also has an expression profile which is consistent with a role in breast cancer progression and metastasis, according to a study published in the March issue of The American Journal of Pathology. Noting that TFF3 is known to stimulate invasion and angiogenesis in vitro, Ahmed R.H. Ahmed, from the University of Newcastle upon Tyne in the United Kingdom, and colleagues examined the expression of TFF3 in 34 normal breast tissue samples, 86 benign breast lesions, 106 in situ breast lesions, and 266 malignant breast lesions. more

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