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Oncolytic Newcastle disease virus for cancer therapy

from Future Microbiology via Medscape

The idea of using bacteria and viruses for treatment of human malignancies initially stemmed from observations during the mid-1800s of tumor regressions that were associated with natural infections. Development of cell and virus culture techniques in the early 1950s led to intensive exploration of virus therapy in small animal tumor models and eventually in humans. Due to significant virulence associated with the use of some of the human pathogens, animal viruses were explored as an alternative, with Newcastle disease virus becoming a promising oncolytic agent. more


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