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Active Voice: Exercise-induced Cardioprotection

from By Scott K. Powers, Ph.D., Ed.D., FACSM; Andreas N. Kavazis, Ph.D.; John C. Quindry, Ph.D., FACSM

Viewpoints presented in SMB commentaries reflect opinions of the authors and do not necessarily reflect positions or policies of ACSM.

Scott Powers, Ph.D., is the UAA Endowed and Distinguished Professor of Applied Physiology and Kinesiology at the University of Florida. His research interests include exercise-induced protection of cardiac and skeletal muscle against stress and the mechanisms responsible for disuse skeletal muscle atrophy.

Andreas Kavazis, Ph.D., is an Assistant Professor of Kinesiology at Mississippi State University. His main research focuses on cardiac mitochondrial adaptations following endurance exercise training.

John Quindry, Ph.D., is an Associate Professor of Kinesiology at Auburn University. His research interests include understanding oxidative stress and mechanisms of exercise-induced cardioprotection against various cardiac pathologies including ischemia-reperfusion injury.

See the March 2012 issue of
Medicine & Science in Sports & Exercise® (MSSE) for two articles related to this topic, which were authored by these three scientists and others from their research teams: “Exercise protects cardiac mitochondria against ischemia-reperfusion injury” and “Evaluation of arrhythmia scoring systems and exercise-induced cardioprotection”.

Cardiovascular disease and specifically ischemia-reperfusion (IR) injury, i.e., heart attack, remains the major cause of death in the industrialized world. Developing strategies to reduce the incidence and severity of IR injury is vital. Numerous investigations clearly demonstrate that regular endurance exercise protects the myocardium during heart attacks. Heart attack protection is a cellular phenomenon which extends to clinically relevant outcomes including tissue preservation, muscle pump function and ventricular arrhythmia prevention (see Miller et al., March, 2012 issue of MSSE). more

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