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Determining drug solubility in polymer by rheological methods

from SPE Plastics Research Online

Hot-melt extrusion has been widely used in the plastics and rubber industry to manufacture a broad variety of products. The process involves mixing different materials using a screw extruder at an elevated temperature and pumping the mixture through a die to form a product of a desired shape. Recently, the process has attracted a great deal of interest from the pharmaceutical industry as a way of avoiding solvents during processing and because it is much more efficient for mass production of generic drugs. more

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