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Gene expression classifier identifies which 'indeterminate' thyroid nodules are benign

from Family Practice News

A novel gene expression classifier was successful in determining which "indeterminate" thyroid nodules are benign and which were "suspicious" in a prospective, multicenter trial. Following fine-needle aspiration analysis, 15-30 percent of thyroid nodules are not clearly benign or malignant. These cytologically indeterminate nodules (including atypia or follicular lesions of undetermined significance and lesions suspicious for follicular/Hurthle cell neoplasm) are often referred for diagnostic surgery, which proves three-fourths to be benign, Dr. Richard Lanman, chief medical officer at Veracyte Inc., said at the annual meeting of the American Association of Clinical Endocrinologists in Philadelphia. more


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