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Innate immunity in donor procurement

from Current Opinion in Organ Transplantation

Ischemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischemia. This review discusses the components of innate immunity known to be involved in renal ischemic reperfusion injury (IRI). Understanding how inflammatory damage is initiated in renal IRI is important for the development of targeted therapies aimed at preserving the donor organ. more

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