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Cancer biology: Targeting tumors with 'stapled' peptides

from Medical Xpress

Cancer biologists consider many cancer-related proteins as "undruggable" because they resist treatments from traditional drugs. David Lane and co-workers at the A*STAR p53 Laboratory, Bioinformatics Institute and Experimental Therapeutics Center are therefore developing a new generation of therapeutics that can reach such proteins and activate their innate cancer-fighting abilities. The team's latest work reveals that 'stapled' peptides — chemically stabilized helices of amino acids — can activate the tumor-suppressing protein p53 inside cells by disrupting interactions with Mdm2, its regulator protein1. more


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