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How should medications be dosed in obese children?

from Medscape

Childhood obesity has been increasing dramatically over the past several years, with its prevalence doubling or tripling between the 1970s and 1990s in numerous countries worldwide. In 2010, the World Health Organization estimated that over 42 million children younger than 5 years are overweight and about 75 percent of these are from developing countries. This population may be at risk for therapeutic failure or adverse drug effects. more

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