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Inherited mutation linked to development of pediatric ALL

from CancerNetwork

A mutation of the PAX5 gene has been found to play an important role in inherited cases of B-cell precursor acute lymphoblastic leukemia (B-ALL). The mutation was isolated in two unrelated families with high propensity for B-ALL. B-ALL is the most common pediatric malignancy, and children with affected siblings have between a twofold and fourfold higher risk of developing the disease. PAX5, a lymphoid transcription factor gene, is mutated in a variety of ways in approximately 30 percent of B-ALL cases. more


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