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Empiric switch from calcineurin inhibitor to sirolimus-based immunosuppression in pediatric heart transplantation recipients

from Pediatric Transplantation (login required)

Sirolimus is used in heart transplant patients with CAV and CNI-induced nephropathy. However, little is known regarding the tolerability, rejection rate and effect on renal function when used empirically in children. This article describes the authors' experience with the empiric use of a sirolimus-based immunosuppressive regimen in pediatric heart transplantation recipients. more

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