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Why dementia drugs work in lab but not in humans

from PsychCentral

In a new study, reported online in the journal Stem Cell Reports, experts suggest why non-steroidal anti-inflammatory drugs — which have successfully treated molecular signs of Alzheimer’s disease in cell and animal models — eventually failed in clinical studies. They discovered that although the compounds worked in non-neuronal cells lines typically used in pharmaceutical drug screening, human neurons are resistant to this class of drugs. more

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