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High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept

from American Journal of Transplantation (login required)

The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high incidence of acute rejection following renal transplantation, which led us to investigate the etiology of belatacept–resistant graft rejection. more

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