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Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function

from Medical Xpress

Investigators at Beth Israel Deaconess Medical Center (BIDMC) report a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements. The new findings, published online in the April 28 issue of Nature, explain how the loss of BRCA1 or BRCA2 function impairs homologous recombination (HR), a normally accurate repair process used to fix DNA breaks, and actually stimulates faulty error-prone HR repair. more


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