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Infectious disease vaccines in the omics era

from Genetic Engineering & Biotechnology News

Advances in sequencing technologies and the increasing availability of microbial genomes catalyzed one of the great strides in vaccinology. This consisted in the shift from conventional vaccines, which are based on inactivated or killed microorganisms or subunit vaccines, to more rationally designed approaches. One of these advances consisted in the development of reverse vaccinology, a genome-based approach in which scanning the entire genome of a pathogen allowed, without the need to grow the microorganism, the identification of genes encoding proteins with certain desirable characteristics, which were then expressed and tested experimentally for their ability to confer protection in vivo. more

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