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Graft-host tolerance in bone marrow transplant chimeras — absence of graft-versus-host disease is associated with unresponsiveness to minor histocompatibility antigens expressed by all tissues

from American Society of Hematology

Because bone marrow (BM) transplantation is used with increasing frequency, it is important to elucidate the mechanisms involved in the establishment of tolerance to host minor histocompatibility antigens (MIHA) in recipients transplanted with T-cell-undepleted marrow grafts. Scientists have previously shown that BM chimeras transplanted across MiHA barriers showed specific unresponsiveness to MiHA expressed on recipient-type concanavalin A blasts. Because expression of many MiHA is tissue-specific, scientists wanted to determine if chimera T-lymphocytes would be tolerant to MiHA expressed by all host tissues and organs. more

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