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Notch signaling and new blood: Tracing the beginnings of hematopoietic stem cells

from University of California, San Diego via Science 2.0

Hematopoietic stem cells are adult stem cells isolated from blood or bone marrow that can renew themselves and differentiate into a variety of specialized cells. They give rise to all other blood cell types, but their development has long remained a mystery. In a new paper, researchers elaborate upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate hematopoietic stem cells from human pluripotent precursors, similar to advances with other kinds of tissue stem cells. more

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