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Identification of protein biomarkers for cervical cancer using human cervicovaginal fluid


A study published the Sept. 12 issue of the PLOS ONE shows that cervicovaginal fluid (CVF) is an excellent source of protein biomarkers for detection of lower female genital tract pathologies and that alpha-actinin-4 derived from CVF is a promising candidate biomarker for the precancerous state of cervical cancer. The proteome analysis revealed 16 candidate biomarkers of which alpha-actinin-4 (p = 0.001) and pyruvate kinase isozyme M1/M2 (p = 0.014) were most promising. more

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