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Ovarian cancer oncogene found in 'junk DNA'

from Oncology Nurse Advisor

A research team mined junk DNA sequences to identify a non-protein-coding RNA whose expression is linked to ovarian cancer in a study published in Cancer Cell. The researchers built a DNA copy number profile for nearly 14,000 long noncoding RNAs, or lncRNAs across 12 cancer types, including ovarian and breast cancers that include the two major BRCA-related cancers. They found that the number of copies of lncRNA genes on a chromosome consistently changes in the 12 different cancer types. Also, lncRNA genes are widely expressed in cancer cells. more

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