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Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands

from American Journal of Transplantation (login required)

We used expression microarrays to characterize the changes most specific for pure T cell–mediated rejection (TCMR) compared to other diseases including antibody-mediated rejection in 703 human kidney transplant biopsies, using a Discovery Set–Validation Set approach. The expression of thousands of transcripts — fold change and association strength—changed in a pattern that was highly conserved between the Discovery and Validation sets, reflecting a hierarchy of T cell signaling, costimulation, antigen-presenting cell (APC) activation and interferon-gamma (IFNG) expression and effects, with weaker associations for inflammasome activation, innate immunity, cytotoxic molecules and parenchymal injury. more

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