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The specific receptor targeted by naltrexone to enhance diabetic wound closure is OGFr

from Society for Experimental Biology and Medicine via Medical Xpress

A major complication associated with diabetes is delayed cell replication in epithelium and skin. Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, have reported the presence and function of the opioid growth factor (OGF) and its nuclear-associated receptor (OGFr) in skin. OGF, an inhibitory growth factor, chemically termed [Met5]-enkephalin, can be upregulated in diabetes leading to depressed cell proliferation. more


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