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Close link between Down syndrome, Alzheimer's disease unlocked by researchers

from Alzheimers News Today

A study entitled "SortingNexin 27 Regulates Aβ Production through Modulatingγ-Secretase Activity" published in the online issue of Cell Reports reveals common molecular mechanisms between Down syndrome and Alzheimer's disease, with clear implications for the development of therapeutics against neuro-disorder diseases. Down syndrome, or trisomy 21 patients — who carry an extra copy of the 21 chromosome — have an increased risk of developing Alzheimer's disease. In fact, nearly 100 percent of DS patients by the age of 40 develop AD-like neuropathology. more


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