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Oestrogen receptor ligands show promise for treating endometriosis

from The Pharmaceutical Journal

Researchers studying endometriosis have discovered a potential way to treat the disease that avoids many of the side effects seen with existing therapies. Two compounds, chloroindazole (CLI) and oxabicycloheptene sulfonate (OBHS), which both bind to oestrogen receptors, were shown to control inflammation and reduce lesions in mice models without affecting fertility. The researchers, led by a team at the University of Illinois at Urbana-Champaign in the United States, say their work, published in Science Translational Medicine, has also provided greater insight into the causes and progression of the disease. more

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