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Benefits of tamoxifen for breast cancer prevention vary among at-risk women

from Healio

Although most women who use tamoxifen for breast cancer prevention will derive benefit, more attention must be paid to the risk–benefit profiles of certain subgroups of at-risk women who may be more likely to experience serious side effects, according to study results published in the Journal of the National Cancer Institute. These subgroups include older women, black women and women who have an intact uterus. Tamoxifen — which received FDA approval in 1998 for primary prevention of breast cancer for women who meet specific age and risk criteria — is not widely used, primarily due to an increased risk for serious adverse effects. Less than 1 percent of eligible women in the United States use tamoxifen for prevention of breast cancer, according to study background. more


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