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New therapeutic strategy discovered for ovarian cancer

from Oncology Nurse Advisor

Researchers have identified a new therapeutic target for a particularly aggressive form of ovarian cancer (ovarian clear cell carcinoma), paving the way for what could be the first effective targeted therapy of its kind for the disease. Their findings were published in Nature Medicine. The researchers observed that ARID1A-mutated ovarian cancers are sensitive to EZH2 inhibition. Most exciting of all, EZH2 inhibition caused the regression of ovarian tumors with mutated ARID1A, while having minimal effects on the growth of ovarian tumor with normal or unmutated ARID1A in experimental models. more

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