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The ultimate mix and match: making sense of HLA alleles and peptide repertoires

from Immunology & Cell Biology

Human leukocyte antigens class I (HLAIs) display protein fragments (~9–13 amino acid peptides primarily generated by proteasomal cleavage of cytosolic proteins) at the cell surface to the adaptive immune system (principally CD8+ T cells). If CD8+ T cells recognize these presented protein fragments, they have the ability to destroy the contaminated cell. HLAIs represent one of the most diverse set of alleles in the human genome, probably an evolutionary safeguard that ensures comprehensive immune disease coverage across the human population. Thus, it is not surprising that particular HLAI alleles are genetically associated with susceptibility to, or protection against, a number of diseases including; HIV-1, type 1 diabetes and ankolysing spondylitis. more


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