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Prognosis after recurrence of hepatocellular carcinoma in liver transplantation: Predictors for successful treatment and survival

from Clinical Transplantation

There are no established prognostic factors or standardized therapies for hepatocellular carcinoma (HCC) recurrence in liver transplantation (LT). The aim of this study was to investigate impact of underlying patient condition on treatment and outcomes of recurrence of HCC after LT. The medical records of 268 LT patients with HCC were evaluated. Potential prognostic factors for survival after recurrence were evaluated, including recurrent tumor characteristics, medical/radiological/surgical therapies for recurrence, and an inflammatory marker (neutrophil/lymphocyte ratio). Laboratory tests at recurrence, including albumin, absolute lymphocyte count (ALC), prognostic nutritional index (PNI: ALC(/μL)x0.005 + Albumin(g/dL)x10) were evaluated as surrogate markers for underlying patient conditions. A total of 51 (19 percent) patients developed HCC recurrence. more

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