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When antidepressants aren't enough for late life depression

from Scienceline

More than half of adults 65 and older with clinical depression don't get better after taking antidepressants. When that happens, physicians are left to rely on educated guesses for what the next step of treatment should be — changing to a different antidepressant, prescribing a second drug in addition to antidepressants, or perhaps psychotherapy. However, a new, large study has found that adding the antipsychotic drug aripiprazole, sold under the brand name Abilify, to traditional antidepressant therapy can relieve depression in many of these patients. Up to 44 percent of patients given aripiprazole in the study achieved remission compared to only 29 percent of patients on placebo. more


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