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Labs must adhere to ASHI standards

From Dr. Myra Coppage, ARB Program Director: The ARB has encountered some confusion with regards to use of appropriate nomenclature for reporting HLA typing results in solid organ transplants. A few labs have been cited at inspection for "mixing" serological and molecular nomenclature on the report. Since the changes to UNOS regulations, labs are required to perform typing using DNA based methods, and results must be reported using W.H.O. molecular nomenclature (e.g. no Cw or DRw). Labs may also choose to report the serological equivalents separately. We realize that the UNET system updates now have labs assigning some loci using molecular designations and others using serological equivalents. However, for reporting purposes, labs must adhere to the relevant ASHI standards:

HLA typing
D.5.2.6.4: Use HLA typing terminology that conforms to the latest report of the World Health Organization (W.H.O.) Nomenclature Committee for factors of the HLA System. Potential new antigens and/or alleles not yet approved by this committee must have a designation that cannot be confused with W.H.O. terminology

Test reports
D.6.2.2.8 The identification of the genetic loci analyzed according to standard nomenclature or published reference. more


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