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Starving cancer cells by blocking their metabolism

from Medical Xpress

Scientists at EPFL have found a way to starve liver cancer cells by blocking a protein that is required for glutamine breakdown— while leaving normal cells intact. The discovery opens new ways to treat liver cancer. Primary liver cancer is the second-leading cause of cancer-related deaths worldwide, and current treatments are very limited. Liver cancer cells are particularly addicted to the amino acid glutamine, which fuels their proliferation. EPFL scientists have now found that a liver protein called "liver receptor homolog 1" is responsible for the digestion of glutamine into smaller molecules, which are avidly consumed by liver cancer cells. more


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