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HLA-A68 and HLA-B15 Alleles Correlate with Poor Immune Response Among AIDS Patients on Combined Antiretroviral Therapy

from Human Immunology

Around 15–30 percent of AIDS patients fail to recover their CD4+ T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. more


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