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Can calcium supplements protect against PPI-induced vitamin B12 deficiency?

from Pharmacy Times

Patients taking acid reducers long term are at greater risk for hypochlorhydria-induced vitamin B12 malabsorption. Both proton pump inhibitors (PPIs) and histamine-2 receptor antagonists can block the activity of intrinsic factor. However, the risk is widely inconsistent across studies due to variable samples and confounding designs. more


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