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Recipients inherit a cardiovascular risk factor from bone marrow donors: Implications for screening of donors?

from American Journal of Transplantation

Previous studies have demonstrated that patients develop de novo cardiovascular risk factors after hematopoietic stem cell transplantation (HSCT). The risk of developing metabolic syndrome in HSCT survivors was increased compared with normal subjects. HSCT survivors were also more likely to develop hyperinsulinemia, impaired glucose tolerance, hypertriglyceridemia, and abdominal obesity than were non-HSCT patients or healthy controls. However, it remains unclear whether increased cardiovascular risk factors are directly associated with transplantation-related factors, including total body irradiation, immunosuppression, and graft-versus-host disease. more

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