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Major family of gene-regulating proteins has drug-sized pocket

from Sanford Burnham Prebys Medical Discovery Institute via Lab Manager

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them. But a new study from scientists at Sanford Burnham Prebys Medical Discovery Institute suggests that a key group of transcription factors are in fact "druggable," including several that could be targeted to treat cancer, metabolic disease or autoimmune conditions. more


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