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Have drug hunters finally cracked KRAS?

from American Chemical Society

From June 9: The ubiquity of KRAS mutations in cancer has made it one of the most desirable drug targets, and yet it is also one of the toughest to tackle. Despite decades of work, researchers still lack detailed information about what the surface of the protein looks like as it moves and interacts with its ligands. That makes finding cracks where small molecules can slip in like trying to climb the sheer face of a mountain while blindfolded. more


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