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Loss of Specific Protein Complex in Cancer Cells May Explain Poor Response to Immunotherapy

from Immuno-Oncology News

Immunotherapies have shown great promise in lung cancer patients, but only a small percentage actually responds to these treatments. Researchers have now shed some light onto why certain lung cancer patients fail to respond to immunotherapy Inactivating mutations in genes that code for the HLA-I (human leukocyte antigen-I) protein complex, which is required for immune recognition, impairs the recruitment and activation of immune cells within tumors, suggesting that this is likely a mechanism used by tumors to escape immune surveillance. more

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