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Intravenous buprenorphine: A substitute for Naloxone in methadone-overdosed patients?

from Annals of Emergency Medicine

Administration of naxolone is a common treatment for opioid-dependent patients who present with respiratory depression. Although safe in opioid-dependent patients, including acute respiratory distress syndrome and myocardian infarction. It has been suggested that administration of buprenorphine, a partial µ-opioid receptor agonist, to an opioid-intoxicated patient may result in reversal of respiratory depression with less severe withdrawal signs and symptoms. more

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