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A new ligand extends the half-life of peptide drugs from minutes to days

from Lab Manager

Peptides are biological molecules, made up of short sequences of amino acids. Because they are easy to synthesize, show low toxicity and high efficiency, peptides such as insulin and other hormones can be used as drugs. But peptides are quickly cleared by the kidneys, which means that we can only use peptide drugs that act within minutes. This problem can be overcome by connecting peptides to ligands that bind blood-serum proteins such as albumin, allowing the peptide to linger in the bloodstream longer. EPFL scientists have now developed such a ligand, which is easy to synthesize and has a high affinity for human albumin. more

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