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Study characterizes proteins resulting from RAS gene mutations, found in more than 20 percent of all human cancers

from Medical Xpress

When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably. This unstoppable cascade inevitably leads to cancer. "The mutation in the gene is very common in pancreatic and colon cancer," said Neil Kelleher, the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences and Medicine at Northwestern University. "But there are currently no drugs that can target the mutation and fix the broken switch." more


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