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MicroRNA-647 Promotes the Therapeutic Effectiveness of Argon-Helium Cryoablation And Inhibits Cell Proliferation Through Targeting TRAF2 Via the NF-kB Signaling Pathway in Non-Small Cell Lung Cancer

from OncoTargets and Therapy

BACKGROUND: MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure. METHODS: The effect of miR-647 and TRAF2 on A549 and H1299 cells was explored through Methyl thiazolyl tetrazolium (MTT) assay, colony formation and cell cycle assays. Luciferase reporter assays, reverse transcription quantitative PCR (RT-qPCR) and Western blot assay were carried out to determine that TRAF2 is directly regulated by miR-647. The effect of miR-647/TRAF2 axis on p65 protein level in nucleus or total was detected by Western blot assay. more

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