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Study Paves Way for Larger Trial on Ventricular Unloading Before PCI

from Cardiovascular Business

The Door-to-Unload pilot study concluded without any “prohibitive safety signals,” researchers reported at the American Heart Association 2018 Scientific Sessions, clearing the path for a larger trial to test the hypothesis that ventricular unloading prior to percutaneous coronary intervention with the Impella CP heart pump can reduce reperfusion injury. That hypothesis is based on preclinical studies which showed that mechanically unloading the left ventricle for 30 minutes before reperfusion for ST-segment elevation myocardial infarction can reduce infarct size and limit reperfusion injury. more

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