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Doubling the dosage of influenza may improve immunogenicity in solid-organ transplant recipients

from By Lynn Hetzler

Influenza infection poses special challenges for solid-organ transplant recipients, as the flu increases their risk for bacterial pneumonia, admission to intensive care, and death. Furthermore, research suggests influenza infection can even increase the risk for allograft rejection and poorer allograft survival. Providing an annual vaccination that contains 15 micrograms of antigen per viral strain is an effective preventative strategy in solid-organ transplant recipients. Now, the results of a new study show that high-dose vaccines possessing 60 micrograms antigen per influenza strain enhance vaccine immunogenicity in this population. more

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