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Parenteral hydromorphone for migraine and ED revisits

from Clinical Pain Advisor

From April 19: Hydromorphone-related "likeability" and "feeling good" may not be associated with return visits to the emergency department in patients treated with the drug for migraine, according to a study published in Headache. To determine the extent to which the nontherapeutic effects of opioids influence migraine outcomes, researchers conducted an ED-based clinical trial, in which 127 patients (mean age 34) with moderate or severe acute migraine were randomly assigned to receive hydromorphone (1 mg intravenously) or prochlorperazine (10 mg) plus diphenhydramine (25 mg). more


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